Abstract
Преждевременные роды остаются одной из важных медико-социальных проблем в охране здоровья матери и ребенка. В данном обзоре показано, что микробиом репродуктивного тракта является ключевым модулятором местных воспалительных и иммунных реакций на протяжении всей беременности и может впоследствии влиять на исходы беременности. Инфекции у матери, прежде всего нарушение состава микрофлоры слизистых вызывает чрезмерный иммунный ответ, который увеличивает выработку провоспалительных цитокинов. Цитокины способствуют как стимуляции нейтрофилов, так и выработке простагландинов, запускают сокращения матки и вызывают повреждение мембраны при преждевременном разрыве околоплодных оболочек и преждевременных родах. Перспективным направлением в предотвращении неблагоприятных перинатальных исходов представляется поиск методов терапии на основе лечения инфекций и коррекции вагинального микробиома.
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https://www.who.int/ru/news-room/fact-sheets/detail/preterm-birth
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